Adaptive Laboratory Evolution
Evolving E. coli 498 under rising reaction-water pressure in continuous culture, tracking how tolerance and growth change run after run.
- Microbial adaptation
- Selection pressure
- E. coli 498
Research
I study whether microbial adaptation can turn a toxic industrial waste stream into something biologically treatable — and how to measure that change rigorously.
Evolving E. coli 498 under rising reaction-water pressure in continuous culture, tracking how tolerance and growth change run after run.
Toxic paint and resin residues from polyester resin production. I test whether the adapted cultures can use those compounds as a carbon source.
Running morbidostat experiments on the Replifactory, with automated dosing and OD600 feedback over long adaptation runs.
Setting up Microtox bioassays with Aliivibrio fischeri to check whether biological treatment lowers acute toxicity. Work in progress.
Python pipelines for time-series analysis and structured lab records in eLabFTW, so experiments stay traceable from raw data to figures.